Without the condescending Nancy Drew claptrap.
Also, Female love interests in said game, please?
I mentioned before that I would adore a Female take on Sherlock Holmes, slightly socially inept, locked in her head a lot, and she and her house mate solve crimes.
Bonus points if the house mate is a kickass female. :D
Or a male that cooks and does the mundane things while still being a BAMF. And doesn't start the dialog for dating, and has to be very carefully pursued, lest he very kindly ask to be friends...
Role Reversal, all the things!